N-cyclohexyl-2-(N-(3-fluorophenyl)-2-(2-Methyl-1H-iMidazol-1-yl)acetaMido)-2-(o-tolyl)acetaMide

Product Name: N-cyclohexyl-2-(N-(3-fluorophenyl)-2-(2-Methyl-1H-iMidazol-1-yl)acetaMido)-2-(o-tolyl)acetaMide
CAS No.: 1355326-35-0
Chemical Name: N-cyclohexyl-2-(N-(3-fluorophenyl)-2-(2-Methyl-1H-iMidazol-1-yl)acetaMido)-2-(o-tolyl)acetaMide
Synonyms: CS-720;AGI5198;IDH-C35;IDH C35;AGI 5196;IDH-C35 /IDHC35;AGI-5198, >=98%;AGI-5198 (IDH-C35);IDH-C35;AGI5198;AGI 5196;AGI5198; AGI-5198; AGI 5198; IDHC35; IDH-C35; IDH C35.
CBNumber: CB52652200
Molecular Formula: C27H31FN4O2
Formula Weight: 462.56
MOL File: 1355326-35-0.mol

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N-cyclohexyl-2-(N-(3-fluorophenyl)-2-(2-Methyl-1H-iMidazol-1-yl)acetaMido)-2-(o-tolyl)acetaMide Property

Boiling point:: 707.6±60.0 °C(Predicted)
Density: 1.21±0.1 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: DMSO: soluble3mg/mL, clear
form: powder
pka: 14.02±0.20(Predicted)
color: white to beige
Stability:: Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
InChIKey: FNYGWXSATBUBER-UHFFFAOYSA-N

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Safety

Hazard Codes: T
Risk Statements: 25
Safety Statements: 45
RIDADR: UN 2811 6.1 / PGIII
WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word: Danger
Hazard statements: H301Toxic if swalloed
Precautionary statements: P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML0839
Product name: IDH-C35
Purity: ≥98% (HPLC)
Packaging: 5mg
Price: $138
Updated: 2023/01/07

Sigma-Aldrich

Product number: SML0839
Product name: IDH-C35
Purity: ≥98% (HPLC)
Packaging: 25mg
Price: $530
Updated: 2023/01/07

Cayman Chemical

Product number: 14624
Product name: AGI-5198
Purity: ≥98%
Packaging: 1mg
Price: $93
Updated: 2024/03/01

Cayman Chemical

Product number: 14624
Product name: AGI-5198
Purity: ≥98%
Packaging: 5mg
Price: $252
Updated: 2024/03/01

Cayman Chemical

Product number: 14624
Product name: AGI-5198
Purity: ≥98%
Packaging: 10mg
Price: $412
Updated: 2024/03/01

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N-cyclohexyl-2-(N-(3-fluorophenyl)-2-(2-Methyl-1H-iMidazol-1-yl)acetaMido)-2-(o-tolyl)acetaMide Chemical Properties,Usage,Production

Description

AGI-5198 (135526-35-0) is a potent (IC50?= 70 nM) inhibitor of mutant isocitrate dehydrogenase 1(IDH1).1? It is selective for the R132H-IDH1 mutant and does not affect wild type cells.2? This mutation results in loss-of-function for oxidative decarboxylation of isocitrate and gain-of-function for production of the oncometabolite R-2-hydroxyglutarate (R-2HG) from alpha-ketoglutarate (2-OG).

Uses

AGI5198 inhibits mutant IDH1 (isocitrate dehydrogenase 1) in cancer cells which delays growth and promotes differentiation of the glioma cells.

Uses

AGI-5198 has been used as a negative control in ligand dilution series.

Biochem/physiol Actions

In human chondrosarcoma cell line JJ012, AGI-5198 promotes apoptosis and G2/M cell cycle arrest. It also prevents the generation of colony in chondrosarcoma cell lines. AGI-5198 hinders the multiplication of cell and induces demethylation of H3K9me3 and H3K27me3.

target

R132H-IDH1

storage

Store at -20°C

References

1) Popovici-Muller?et al. (2012),?Discovery of the First Potent Inhibitors of Mutant IDH1 That Lower Tumor 2-HG In Vivo; ACS Med. Chem. Lett.,?3?850 2) Rohle?et al. (2013),?An inhibitor of mutant IDH1 delays growth and promotes differentiation of glioma cells; Science,?340?626

N-cyclohexyl-2-(N-(3-fluorophenyl)-2-(2-Methyl-1H-iMidazol-1-yl)acetaMido)-2-(o-tolyl)acetaMide Preparation Products And Raw materials

Raw materials

Preparation Products

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N-cyclohexyl-2-(N-(3-fluorophenyl)-2-(2-Methyl-1H-iMidazol-1-yl)acetaMido)-2-(o-tolyl)acetaMide Suppliers

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1355326-35-0, N-cyclohexyl-2-(N-(3-fluorophenyl)-2-(2-Methyl-1H-iMidazol-1-yl)acetaMido)-2-(o-tolyl)acetaMideRelated Search:

ZM 447439 Ko 143 CYCLOPAMINE SU 4312 AGI6780 BI 2536 Veliparib Ibrutinib Rapamycin PLX4032

AGI-5198 (IDH-C35)

N-cyclohexyl-2-(N-(3-fluorophenyl)-2-(2-Methyl-1H-iMidazol-1-yl)acetaMido)-2-(o-tolyl)acetaMide

IDH-C35 /IDHC35

N-CYCLOHEXYL-2-(N-(3-FLUOROPHENYL)-2-(2-METHYL-1H-IMIDAZOL-1-YL)ACETAMIDO)-2-(O-TOLYL)ACETAMIDE;AGI5198;IDH-C35 /IDHC35

IDH C35

IDH-C35

AGI5198

N-[2-(Cyclohexylamino)-1-(2-methylphenyl)-2-oxoethyl]-N-(3-fluorophenyl)-2-methyl-1H-imidazole-1-acetamide

1H-Imidazole-1-acetamide, N-[2-(cyclohexylamino)-1-(2-methylphenyl)-2-oxoethyl]-N-(3-fluorophenyl)-2-methyl-

N-[2-(Cyclohexylamino)-1-(2-methylphenyl)-2-oxoethyl]-N-(3-fluorophenyl)-2-methyl-1H-imidazole-1-acetamide AGI 5198

N-Cycohexyl-2-(N-(3-fluorophenyl)-2-(2-methyl-1H-imidazol-1-yl)acetamido)-2-(o-tolyl)acetamide

AGI-5198, >=98%

AGI 5196

IDH-C35;AGI5198;AGI 5196

CS-720

AGI5198; AGI-5198; AGI 5198; IDHC35; IDH-C35; IDH C35.

N-cyclohexyl-2-(N-(3-fluorophenyl)-2-(2-Methyl-1H-iMidazol-1-yl)acetaMido)-2-(o-tolyl)acetaMide USP/EP/BP

N-cyclohexyl-2-(3-fluoro-N-[2-(2-methylimidazol-1-yl)acetyl]anilino)-2-(2-methylphenyl)acetamide

IDH1 Inhibitor R132 Somatic Mutant-Specific AGI-5198 AGI5198

1355326-35-0

C27H31FN4O2

Inhibitors

apis